Study on the relationship between Fas expression and apoptosis in oral squamous cell carcinoma.
- Author:
Jian-guang WANG
1
;
Hong-zhang HUANG
;
Chao-bin PAN
;
Jin-song HOU
;
Jin-song LI
;
Bin CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; Carcinoma, Squamous Cell; metabolism; Humans; Mouth Neoplasms; metabolism; fas Receptor; metabolism
- From: West China Journal of Stomatology 2004;22(4):334-336
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of Fas mRNA and protein expression and apoptosis in human oral squamous cell carcinoma.
METHODSNorthern blot and flow cytometry (TUNEL method) were used to detect the expression of Fas mRNA and Fas protein, cell cycle and apoptotic level in oral squamous cell carcinoma. The relationship between Fas gene expression and OSCC apoptosis was analyzed statistically.
RESULTSFas mRNA and protein could be detected in all five normal oral mucosa specimens. There was positive correlation between expression of Fas mRNA/protein and cell differentiation as well as apoptosis in OSCC (P < 0.005).
CONCLUSIONThe expression of Fas gene was highly correlated with the differentiation and apoptosis in OSCC.
