An experimental study on PLGA carrier for oral tissue engineered mucosa by subcutaneous implantation in rabbits.
- Author:
Bing QI
1
;
Hong-wei LI
;
Yu-ming WEN
;
Chang-mei WANG
;
Long-jiang LI
;
Xiao-ling SONG
Author Information
- Publication Type:Journal Article
- MeSH: Absorbable Implants; Animals; Biocompatible Materials; Cells, Cultured; Female; Lactic Acid; metabolism; Male; Mouth Mucosa; cytology; metabolism; Polyglycolic Acid; metabolism; Polymers; metabolism; Rabbits; Tissue Engineering
- From: West China Journal of Stomatology 2004;22(5):362-365
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo look for the best carrier for cultivating oral tissue engineered mucosa.
METHODSA series of membrane of scaffold materials of polycleclide-co-plycoclide (PLGA) were studied on their weight and biocompatibility after they had been implanted subcutaneously in rabbits for 1, 2, 3, 4 weeks respectively.
RESULTSPLGA I , II, III degraded completely in rabbits after 2, 3, 4 weeks respectively. The other PLGA membrane degraded about 50% after 4 weeks. Histologically, the reactions of PLGA I, II, III with surrounding tissues were normal and membranes had a good biocompatibility.
CONCLUSIONThe biodegrading rate of PLGA II is suitable for clinic practice. PLGA II was a promising carrier for oral tissue-engineered mucosa due to its excellent biocompatibility and biodegrading rate.
