Expression of telomerase activity and c-myc and stimulatory protein 1 in human ameloblastoma.
- Author:
Ming ZHONG
1
;
Zi-juan LI
;
Jie WANG
;
Bo ZHANG
;
Lin HOU
;
Yan-bing GONG
Author Information
- Publication Type:Journal Article
- MeSH: Ameloblastoma; metabolism; Humans; Proto-Oncogene Proteins c-myc; metabolism; Sp1 Transcription Factor; metabolism; Telomerase; metabolism
- From: West China Journal of Stomatology 2004;22(6):499-502
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the oncogene transcriptor c-myc, stimulatory protein 1 (SP1) expression in ameloblastoma (AB) and their relation with telomerase reverse transcripase (hTERT), and to investigate the clinical biological characteristics of AB.
METHODSThe expression was observed in AB by in situ hybridization and SP method.
RESULTSThe positive rates of c-myc mRNA, hTERT mRNA and SP1 protein were 81.5% (44/54), 94.4% (51/54) and 83.3% (45/54), respectively. Their positive rates increased as AB recurred and transformed malignantly. A strong correlation was found between hTERT and c-myc, hTERT and SP1 (rs = 0.853, P < 0.001; rs = 0.900, P < 0.001).
CONCLUSIONActivity of telomerase plays an important role in the tumorigenesis development of AB. Increasing of hTERT expression may be related to c-myc and SP1. The expression of these three parameters has a significant correlation with the clinical biological characteristics of AB.
