Expression and significance of angiopoietins in oral squamous cell carcinoma.
- Author:
Yun-xia WU
1
;
Ping LIANG
;
Xin-rong NAN
;
Yan-jun JIAO
;
Xiao-jun SUN
Author Information
- Publication Type:Journal Article
- MeSH: Angiopoietin-1; Angiopoietin-2; Angiopoietins; Carcinoma, Squamous Cell; Humans; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Neoplasms; Neovascularization, Pathologic
- From: West China Journal of Stomatology 2005;23(1):63-68
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the expression of angiopoietins in oral squamous cell carcinoma and relationship between the expression of angiopoietins and pathologic classification.
METHODSThe expression of Ang-1 and Ang-2 protein in samples from 42 oral squamous cell carcinoma and 16 oral normal mucosa were detected by immunohistochemical technique.
RESULTSThe expression of Ang-1 and Ang-2 was found in both oral squamous cell carcinoma and normal control. It was found Ang-1 expression alike in oral squamous cell carcinoma and control (P > 0.05). Ang-2 expressed at low level in control while strongly positive in oral squamous cell caroinoma and the level of Ang-2 expression in oral squamous cell caroinoma was related to pathologic classification (P < 0.05).
CONCLUSIONAng-2 expression in oral squamous cell carcinoma is related to angiogenesis and pathological classification, which is probably involved in angiogenesis regulation, promotes the development and metastasis of oral squamous cell carcinoma.
