Cis-CA1P inhibits tumor cell proliferation and prevents blood vessel formation.
- Author:
Yuan-Zheng XIA
1
;
Yong YANG
;
Zhuo WANG
;
Jing-Jing DUAN
;
Xian-Jing LI
;
An-Peng ZHAO
;
Xiu-Lan SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aorta; drug effects; Cell Line, Tumor; Cell Proliferation; drug effects; Chick Embryo; Chorioallantoic Membrane; blood supply; drug effects; Humans; In Vitro Techniques; Neovascularization, Pathologic; prevention & control; Phosphates; pharmacology; Rats; Stilbenes; chemistry; pharmacology
- From: Chinese Journal of Applied Physiology 2012;28(1):15-18
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of cis-combretastatin-A1 phosphate (cis-CA1P) on tumor cell proliferation, and its effects on the blood vessel formations.
METHODSMTT and IC50 values were used to assess the inhibitory effects of cis-CA1P on tumor cell proliferation. Chicken embryo chorioallantoic membrane and thoracic aorta annulations isolated from rats were used to investigate the effects of cis-CAIP on the blood vessel formation.
RESULTSCis-CA1P concentration-dependently inhibited the proliferations of several cancer cell lines, including human gastric carcinoma cell line MGC-803, human leukemic monocyte lymphoma cell line U937, human melanoma cell line A375, human colon cancer cell line HCT116, human breast carcinoma cell line MDA-MB-231, and human leukemia cell line K562. Cis-CAIP significantly decreased the formation of blood vessels in chicken embryo chorioallantoic membrane and in thoracic aorta annulations.
CONCLUSIONCis-CA1P inhibits cancer cell proliferation and prevents blood vessel formation.
