Effects of alpha-linolenic acid on inflammation and oxidative stress in the diabetic rats.
- Author:
Li-Hua ZHANG
1
;
Wei ZHANG
;
Guang-Hong WEI
;
Pei YANG
;
Jun LIU
;
Xiao-Lin NIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Diabetes Mellitus, Experimental; drug therapy; metabolism; Diabetes Mellitus, Type 2; drug therapy; metabolism; Inflammation; Male; Malondialdehyde; blood; Oxidative Stress; drug effects; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; blood; Tumor Necrosis Factor-alpha; blood; alpha-Linolenic Acid; pharmacology; therapeutic use
- From: Chinese Journal of Applied Physiology 2012;28(1):64-67
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of alpha-linolenic acid (ALA) on inflammation and oxidative stress in the diabetic rats.
METHODSAn experimental type 2 diabetes mellitus model was induced by feeding male SD rats with diet of high fat for 4 weeks and then injected them intraperitoneally with streptozocin (STZ) at 30 mg/kg. Then the animals were randomly divided into three groups (n = 10): control group, diabetic group and ALA group. Four weeks later, tumor necrosis factor (TNF)-a, soluble P-selectin (sP-selectin), soluble intercellular adhesion molecule-1 (sICAM-1), nitric oxide (NO) production, malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) in the serum were determined.
RESULTSInflammatory agents including TNF-alpha, sP-selectin and sICAM-1 increased in diabetic rats to compare with control group. Treatment with ALA significantly decreased TNF-alpha, sP-selectin and slCAM-1 to compare with diabetic group. Furthermore, compared with control group, serum MDA production increased whereas NO production, SOD and CAT activities decreased in diabetic rats. Treatment with ALA reduced MDA production, increased NO production, promoted SOD and CAT activities compared with diabetic group.
CONCLUSIONThese results indicate that diet rich in ALA exerted the anti-inflammatory and anti-oxidative effects in diabetic rats, which may be beneficial to the prevention and treatment of diabetes.
