Expressions of E-cadherin, Cortactin and MMP-9 in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma of the Head and Neck: Their Relationships with Clinicopathologic Factors and Prognostic Implication.
10.4132/KoreanJPathol.2012.46.4.331
- Author:
Tack Kune YOU
1
;
Kyoung Min KIM
;
Sang Jae NOH
;
Jun Sang BAE
;
Kyu Yun JANG
;
Myoung Ja CHUNG
;
Woo Sung MOON
;
Myoung Jae KANG
;
Dong Geun LEE
;
Ho Sung PARK
Author Information
1. Department of Pathology, Chonbuk National University Medical School, Jeonju, Korea. hspark@jbnu.ac.kr
- Publication Type:Original Article
- Keywords:
Carcinoma, squamous cell;
Pseudoepitheliomatous hyperplasia;
Cadherins;
Cortactin;
Matrix metalloproteinase 9;
Head and neck neoplasms
- MeSH:
Cadherins;
Carcinoma, Squamous Cell;
Cortactin;
Diagnosis, Differential;
Head;
Head and Neck Neoplasms;
Hyperplasia;
Matrix Metalloproteinase 9;
Neoplasm Metastasis;
Prognosis;
Recurrence
- From:Korean Journal of Pathology
2012;46(4):331-340
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: E-cadherin, cortactin, and matrix metalloproteinase (MMP)-9 have roles in tumor development or progression, but their expression has not been fully investigated in pseudoepitheliomatous hyperplasia (PEH) and squamous cell carcinoma (SCC) of the head and neck. METHODS: We evaluated the immunohistochemical expression of E-cadherin, cortactin, and MMP-9 in 29 cases of PEH and 97 cases of SCC. Additionally, we evaluated their relationship with clinicopathologic factors and prognostic implications in SCC. RESULTS: Thirty-five cases of SCC showed reduced expression of E-cadherin, whereas none of the PEH did. A total of 20 cases and 11 cases of SCC were immunoreactive for cortactin and MMP-9, respectively, whereas none of the PEH did. In SCC, reduced expression of E-cadherin was correlated with cortactin expression and invasion depth. Cortactin expression was correlated with differentiation, T classification, and recurrence and/or metastasis. MMP-9 expression was correlated with invasion depth. Cortactin expression was correlated with poor overall survival and relapse-free survival and it was an independent prognostic factor. CONCLUSIONS: The reduced expression of E-cadherin and the expression of cortactin may be helpful for the differential diagnosis of PEH and SCC. Furthermore, cortactin expression in association with reduced E-cadherin expression is correlated with poor prognosis in SCC.