OBJECTIVETo investigate the effect of the "compound extract of Chinese medicine" on free radical metabolism and antioxidant enzyme systems of the rat brain.

METHODS70 Wistar mice were randomly divided into two groups (n = 35): normal control group (N), taking medicine group (M). After a week of feeding, M group was taking medicine for 8 weeks. After 9 weeks, killed the two groups when they were at the rest state, the immediate ends of the fixed load, the immediate ends of exhaustive exercise and 12, 24 hour ends of exhaustive exercise, respectively. And the activity of malonaldehyde (MDA), glutathione peroxidase (GSH-PX), glutathione (GSH), superoxide dismutase (SOD), total anti oxidation capacity (T-AOC) of the rat brain were measured.

RESULTSAt the five states, the content of MDA in M group was lower than that in N group in different degree, the activity of GSH-PX, GSH, SOD, T-AOC in M group were higher than those in N group in different degree.

CONCLUSIONThe "Compound extract of Chinese medicine" can reduce the MDA level of the rat brain and improve the enzyme activity of GSH-PX, GSH, SOD, T-AOC.