Correlation analysis of aspirin resistance and cycloxygenase-1 haplotype in old Chinese patients with cardio-cerebrovascular diseases.
- Author:
Xiao-li LI
1
;
Jian CAO
;
Li FAN
;
Ling YE
;
Qiang WANG
;
Chun-ping CUI
;
Lin LIU
;
Feng-chun ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Asian Continental Ancestry Group; genetics; Aspirin; pharmacology; Cardiovascular Diseases; genetics; Case-Control Studies; Cerebrovascular Disorders; genetics; Cyclooxygenase 1; genetics; Drug Resistance; genetics; Female; Genotype; Haplotypes; Humans; Male; Polymorphism, Single Nucleotide
- From: Chinese Journal of Applied Physiology 2012;28(3):225-229
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate whether cyclooxygenase-1 (COX-1) haplotype is associated, with aspirin resistance.
METHODSThe participants were 431 old Chinese Han patients with cardiovascular and cerebrovascular diseases who took aspirin. The 59 patients with aspirin resistance (AR) by light transmittance aggregation acted as the cases; the 372 aspirin-sensitive patients were the controls. The relationships between AR and 6 single nucleotide polymorphisms (SNPs) in COX-1 gene. rs1888943 (8759C/T), rs1330344 (1676A/G), rs3842787 (exon2, 50C/T, p.Pro17Leu), rs5787 (exon 4, 323G/A, p. ARg108Gln), rs5789 (exon7, 709C/A, p. Leu237Met) and rs5794 (exonl0, 1330G/A, p.Va1481Ile) were investigated by the USA Sequenom high-throughput single nucleotide polymorphisms (SNP) genotyping systems.
RESULTSIn this case-control trial, the frequency of mutant CGCGCC-haplotype in case was 0.48 (57/118) and in control was 0.39 (286/742), which was significantly higher than that of the control group (P < or = 0.05).
CONCLUSIONCOX-1 haplotype is associated with aspirin resistance in old Chinese Han patients with cardio-cerebrovascular diseases, mutant CGCGCC-haplotype carriers of COX-1 has a significant significantly increased risk of AR.
