The effects of pH0 on electrophysiological properties of VSMCs in brain artery of spontaneously hypertensive rats.
- Author:
Yuan-yuan SHANG
1
;
Jun-qiang SI
;
Li LI
;
Yu LIAN
;
Ke-tao MA
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cerebral Arteries; cytology; Electrophysiological Phenomena; Extracellular Fluid; physiology; Hydrogen-Ion Concentration; Muscle, Smooth, Vascular; physiology; Rats; Rats, Inbred SHR
- From: Chinese Journal of Applied Physiology 2012;28(3):268-270
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of pH0 on the electrophysiological properties of vascular smooth muscle cells (VSMCs) in brain artery of spontaneously hypertension rats (SHR).
METHODSWe studied the effects and the ion mechanism of pH0 on whole-cell membrane current of VSMCs in brain artery of 200 - 250 g SHR by whole-cell patch clamp recordings.
RESULTS1. Acidic pH0 could inhibit the outward current of VSMCs of brain artery in SHR in a voltage-dependent manner. It induced a more pronounced inhibition of the outward current from 0 to + 60mV; 2. In the presence of 1 mmol/L TEA, the inhibition of acidic pH0 on the outward current of VSMCs of brain artery was inhibited.
CONCLUSIONThe changes of outward current of VSMCs of brain artery in SHR induced by pH0 may be connected with BKCa channel.
