Histone modifications during spermatogenesis and male infertility.
10.3881/j.issn.1000-503X.2014.01.020
- Author:
Xiao-yan PAN
1
;
Zhi-xin LI
1
;
Zheng-chao WANG
2
;
Xue-nan WANG
3
;
Bing-yang HUANG
1
;
Zhao-hua DOU
1
;
Yan-mei SUN
4
Author Information
1. Department of Histology and Embryology, Jilin Medical College, Jilin, Jilin 132013, China.
2. Provincial Key Laboratory for Developmental Biology and Neuroscience, College of Life Science, Fujian Normal University, Fuzhou 350007, China.
3. Reproductive Medicine Center, the Affiliated Hospital of Jining Medical College, Jining, Shandong 272029, China.
4. Department of Inspection, Jilin Medical College, Jilin, Jilin 132013, China.
- Publication Type:Journal Article
- MeSH:
Epigenesis, Genetic;
Histones;
metabolism;
Humans;
Infertility, Male;
physiopathology;
Male;
Spermatogenesis
- From:
Acta Academiae Medicinae Sinicae
2014;36(1):108-113
- CountryChina
- Language:Chinese
-
Abstract:
Many pathological phenomena of male infertility are related to epigenetic changes in male germ cells. Epigenetic regulation during spermatogenesis plays an important role in mitotic/meiotic divisions and spermiogenesis. The histones have various post-translational modifications on different amino acid residues during spermatogenesis. These modifications are crucial to the precise regulation of spermatogenesis. Moreover, the histone-to-protamine transition will occur during spermiogenesis. Many studies have also found that abnormal changes of histone modifications during spermatogenesis may damage the sperm development, leading to male sterility. This article reviews the changes of histone modifications during spermatogenesis, the regulation of the development of male germ cells, and the relationship between histone abnormalities and male sterility.
