Research advances in the expression of co-stimulatory molecules and signaling pathways in γδT cells.
10.3881/j.issn.1000-503X.2014.02.022
- Author:
Yi BAO
1
;
Li GUO
1
Author Information
1. Key Laboratory of Jiaxing Second Hospital,Jiaxing, Zhejiang 314000,China.
- Publication Type:Journal Article
- MeSH:
Humans;
Lymphocyte Activation;
physiology;
Signal Transduction;
T-Lymphocyte Subsets;
physiology
- From:
Acta Academiae Medicinae Sinicae
2014;36(2):223-226
- CountryChina
- Language:Chinese
-
Abstract:
Human T lymphocytes are divided into αβT cells and γδT cells on the basis of the different expressions of T cell receptors. In recent years, the studies of the regulation of T cell activation and tolerance by co-stimulatory molecules and their signaling pathways in αβT cell have made remarkable progress; however, relatively fewer investigations have been performed on γδT cells. A clearer understanding of the roles of co-stimulatory molecules and their signaling pathways in the positive/negative regulation of γδT cells at different stages will provides new insights for the treatment of viral infections, cancer, autoimmune diseases, transplant rejection, and other conditions.
