Association between EHD3 gene and the cognitive function of patients with major depressive disorder.

Le Wang; Cui-juan Shi; Qi XU

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Association between EHD3 gene and the cognitive function of patients with major depressive disorder.

Author: Le WANG ¹ ; Cui-juan SHI ² ; Qi XU ¹
Author Information

1. National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China.
2. Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System of Ministry of Education, Tianjin Key Laboratory of Injuries,Variations,and Regeneration of the Nervous System, Department of Neuropathology,Tianjin Neurologic Institute,Tianjin Medical University General Hospital,Tianjin 300052,China.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Carrier Proteins; genetics; Case-Control Studies; Cognition; Depressive Disorder, Major; genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Young Adult
From: Acta Academiae Medicinae Sinicae 2014;36(3):227-233
CountryChina
Language:English
Abstract:
OBJECTIVETo analyze the potential association between the EHD3 gene and the cognitive function of patients with major depressive disorder (MDD).
METHODSA total of 47 MDD patients and 40 healthy controls were enrolled in this study. After their cognitive functions were analyzed, the scores of the MDD patients were used as the quantitative traits; by using the quantitative trait module in the UNPHASED software, we analyzed the potential association of the cognitive traits with the EHD3 gene.
RESULTSThe cognitive scores (WAIS-RC and WMS-R) of MDD patients were significantly lower than those of controls (P<0.05). The rs3769621 allele and genotype of EHD3 gene were significantly associated with the raw score and scaled score of WAIS-RC (Χ(2)=10.561, P=0.001; Χ(2)=7.922, P=0.019; Χ(2)=12.627, P=0.00038; Χ(2)=11.775, P=0.0027)and WMS-R (Χ(2)=8.762, P=0.003; Χ(2)=17.399, P=0.00016; Χ(2)=10.356, P=0.001; Χ(2)=14.958, P=0.00056). Such associations remained statistically significant after Bonferroni correction.
CONCLUSIONThe EHD3 gene may be associated with the endophenotype of cognitive function in MDD patients.