Association between EHD3 gene and the cognitive function of patients with major depressive disorder.
- Author:
Le WANG
1
;
Cui-juan SHI
2
;
Qi XU
1
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Carrier Proteins; genetics; Case-Control Studies; Cognition; Depressive Disorder, Major; genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Young Adult
- From: Acta Academiae Medicinae Sinicae 2014;36(3):227-233
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo analyze the potential association between the EHD3 gene and the cognitive function of patients with major depressive disorder (MDD).
METHODSA total of 47 MDD patients and 40 healthy controls were enrolled in this study. After their cognitive functions were analyzed, the scores of the MDD patients were used as the quantitative traits; by using the quantitative trait module in the UNPHASED software, we analyzed the potential association of the cognitive traits with the EHD3 gene.
RESULTSThe cognitive scores (WAIS-RC and WMS-R) of MDD patients were significantly lower than those of controls (P<0.05). The rs3769621 allele and genotype of EHD3 gene were significantly associated with the raw score and scaled score of WAIS-RC (Χ(2)=10.561, P=0.001; Χ(2)=7.922, P=0.019; Χ(2)=12.627, P=0.00038; Χ(2)=11.775, P=0.0027)and WMS-R (Χ(2)=8.762, P=0.003; Χ(2)=17.399, P=0.00016; Χ(2)=10.356, P=0.001; Χ(2)=14.958, P=0.00056). Such associations remained statistically significant after Bonferroni correction.
CONCLUSIONThe EHD3 gene may be associated with the endophenotype of cognitive function in MDD patients.