Combination chemotherapy regimen with floxuridine, dactinomycin, etoposide, and vincristine as primary treatment for gestational trophoblastic neoplasia.
- Author:
Tao WANG
1
;
Feng-zhi FENG
1
;
Yang XIANG
1
;
Xi-run WAN
1
;
Tong REN
1
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Dactinomycin; administration & dosage; Etoposide; administration & dosage; Female; Floxuridine; administration & dosage; Gestational Trophoblastic Disease; drug therapy; Humans; Middle Aged; Pregnancy; Retrospective Studies; Treatment Outcome; Vincristine; administration & dosage; Young Adult
- From: Acta Academiae Medicinae Sinicae 2014;36(3):300-304
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the combination chemotherapy regimen with floxuridine, dactinomycin, etoposide, and vincristine (FAEV) as primary treatment for gestational trophoblastic neoplasia (GTN).
METHODSClinical data and outcome of the patients with GTN from 1 January 2004 to 31 December 2009 were retrospectively reviewed. Totally 38 eligible patients had received at least one cycle of FAEV chemotherapy as primary treatment. The primary end points were response rate and toxicity of FAEV regimen.
RESULTSTotally 38 patients and 205 cycles of FAEV chemotherapy were included. Twenty-eight of these patients (73.6%) achieved serologic complete remission (SCR). Regimens were changed in 10 patients because of 5 with no response and 5 with intolerable toxicity. The most serious adverse events were greater than or equal to grade 3 neutropenia (31.6%), febrile neutropenia (7.9%), and greater than or equal to grade 3 thrombocytopenia (5.3%). During the follow-up, none relapsed.
CONCLUSIONFAEV is an effective regimen with manageable toxicity for patients with GTN as primary treatment, especially for patients with non-metastatic low or high risk GTN.
