A voxel-based morphometry study of grey matter volume changes in neuromyelitis optica patients.

Author: Cong CHEN ¹ ; Bo HOU ¹ ; Hui YOU ¹ ; Yue-lei LV ¹ ; Yan XU ² ; Feng FENG ¹
Author Information

1. Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
2. Department of Neurology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Case-Control Studies; Female; Gray Matter; pathology; Humans; Magnetic Resonance Imaging; Male; Neuromyelitis Optica; pathology; Young Adult
From: Acta Academiae Medicinae Sinicae 2014;36(4):432-438
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the grey matter volume (GMV) changes in neuromyelitis optica (NMO) patients using a voxel-based morphometry method.
METHODSWhole brain structural images were acquired in 16 NMO patients and 16 gender-and age-matched healthy controls. Comparison of GMV between the two groups was analyzed by VBM8 toolbox of statistical parametric mapping 8.
RESULTCompared with the controls, NMO patients showed decreased GMV in the frontal lobe, parietal lobe, temporal lobe, occipital lobe, limbic lobe, optic tract, caudate nucleus, thalamus, and cerebellum (all P < 0.005).
CONCLUSIONSRegional atrophy of grey matter is found in NMO patients. Voxel-based morphometry can reveal brain volume changes sensitively.