Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology Diagnosis of Solid Pseudopapillary Neoplasm: Three Case Reports with Review of Literature.
10.4132/KoreanJPathol.2012.46.4.399
- Author:
Joon Seon SONG
1
;
Chong Woo YOO
;
Youngmee KWON
;
Eun Kyung HONG
Author Information
1. Department of Pathology, Center for Liver Cancer, National Cancer Center, Goyang, Korea. hongek@ncc.re.kr
- Publication Type:Case Report
- Keywords:
Solid pseudopapillary neoplasm;
Endoscopic ultrasound-guided fine needle aspiration;
Cytology
- MeSH:
Biopsy, Fine-Needle;
Diagnostic Errors;
Endoscopic Ultrasound-Guided Fine Needle Aspiration;
Female;
Humans;
Male;
Pancreas
- From:Korean Journal of Pathology
2012;46(4):399-406
- CountryRepublic of Korea
- Language:English
-
Abstract:
Solid pseudopapillary neoplasm of the pancreas (SPN) is relatively rare and it occurs almost exclusively in women. We recently experienced three cases of SPN diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). These three cases were two male and one female patient whose age was 29, 37, and 44 years old. Radiological diagnosis was pancreatic endocrine tumor (PEN) showing solid with a heterogenous echogenicity. EUS-FNA cytology specimens consisted of single cells and aggregates of uniform cells, forming microadenoid structures, branching, papillary clusters with delicate fibrovascular cores. In conclusion, a single diagnosis of SPN based on clinical and radiological findings would be risky because there is a possibility of it being misdiagnosed as PEN or other malignancies. An EUS-FNA is therefore essential for establishing the diagnosis. In addition, the pathologists should recognize the characteristic cytologic findings with immunoprofiles of SPN to prevent misdiagnosis of SPN.
