Effects of dipeptidyl peptidase-4 on the hematopoiesis and transplantation.
10.3881/j.issn.1000-503X.2014.05.016
- Author:
De-guan LI
1
;
Ai-min MENG
1
Author Information
1. Tianjin Key Laboratory of Radiation Medicine and Nuclear Medicine,Institute of Radiation Medicine,CAMS and PUMC,Tianjin 300192,China.
- Publication Type:Journal Article
- MeSH:
Dipeptidyl Peptidase 4;
physiology;
Hematopoiesis;
Hematopoietic Stem Cell Transplantation;
Humans
- From:
Acta Academiae Medicinae Sinicae
2014;36(5):538-541
- CountryChina
- Language:Chinese
-
Abstract:
Dipeptidyl peptidase-4 (DPP-4) is a protease that cleaves the peptides with alanine, praline, or other selective amino acids at the N-terminal penultimate position. The substrates of DPP-4 include many chemokines, colony-stimulating factors, and interleukins. Recent research has shown that DPP-4 can affect the hematopoietic stem and progenitor cells and transplantation by truncating the granulocyte colony stimulating factor. However, its regulatory effect on DPP-4 and most peptides truncation are still unknown. This review summarizes the recent advances in the DPP-4 research.
