Determination of the content of residual solvents in Haikesu I by head-space gas chromatography.
- Author:
Xuan XIAO
1
;
Dong LIU
1
;
Ke-Min WANG
2
;
Jia-Zhi CHEN
3
;
Shu ZHANG
2
Author Information
- Publication Type:Journal Article
- MeSH: Acetone; analysis; Chromatography, Gas; Drugs, Chinese Herbal; chemistry; Ethanol; analysis; Flame Ionization; Methanol; analysis; Solvents; analysis
- From: Acta Academiae Medicinae Sinicae 2014;36(6):599-601
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo explore the usefulness of head-space gas chromatography for the determination of methanol and ethanol in Haikesu I,a raw material of artificial musk.
METHODSThe determination was performed on HP-5(30 m×0.53 mm,5 Μm)capillary column with an hydrogen flame ionization detector. The solvent was dimethyl sulfoxide and the internal standard was acetone. The injector temperature and the detector temperature were controlled at 180 ℃ and 250 ℃,respectively. The carrier gas was nitrogen. The containers of head-space injector were preheated at 90 ℃ for 15 minutes. The column temperature was programmed raised,which achieved baseline separation of the components.
RESULTSThe results showed a good linear relationship for methanol and ethanol in their linearity range;and the limit of detection was 0.8 and 1.0 Μg/ml,respectively. The precision and average recoveries were satisfactory.
CONCLUSIONThe head-space gas chromatography is simple,rapid,and precise technique for the measurement of residual solvents in Haikesu I.
