Determination of the content of residual solvents in Haikesu 2 by head-space gas chromatography.
- Author:
Xuan XIAO
1
;
Dong LIU
1
;
Ke-Min WANG
2
;
Jia-Zhi CHEN
3
;
Shu ZHANG
2
Author Information
- Publication Type:Journal Article
- MeSH: Acetates; analysis; Chromatography, Gas; Drugs, Chinese Herbal; chemistry; Fatty Acids, Monounsaturated; chemistry; Flame Ionization; Solvents; analysis
- From: Acta Academiae Medicinae Sinicae 2014;36(6):602-605
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo determine ethylacetate and petroleum ether(60-90 ℃)in Haikesu 2,which is one of the raw materials of artificial musk,using the head-space gas chromatography.
METHODSThe determination was performed on HP-5(30 m×0.53 mm,5 Μm)capillary column with an hydrogen flame ionization detector. The solvent was dimethyl sulfoxide and the internal standard was methanol. The injector temperature and the detector temperature were controlled at 180 ℃ and 250 ℃,respectively. The carrier gas was nitrogen. The containers of head-space injector were preheated at 90 ℃ for 15 minutes. The column temperature was programmed raised,which achieved baseline separation of the components.
RESULTSThe results showed a good linear relationship for ethylacetate and petroleum ether(60-90 ℃)in their linearity range;and the limit of detection was 0.7 and 0.3 Μg/ml,respectively. The good precision and good average recoveries were satisfactory.
CONCLUSIONThe head-space gas chromatography is simple,rapid,and precise technique for the measurement of residual solvents in Haikesu 2.
