Determination of the content of residual solvents in muscone by head-space gas chromatography.
- Author:
Dong LIU
1
;
Ke-Min WANG
2
;
Xuan XIAO
1
;
Li-Jun LUN
3
;
Shu ZHANG
2
;
Author Information
- Publication Type:Journal Article
- MeSH: Chromatography, Gas; Cycloparaffins; chemistry; Drug Contamination; Drugs, Chinese Herbal; chemistry; Ethanol; analysis; Solvents; analysis
- From: Acta Academiae Medicinae Sinicae 2014;36(6):606-609
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo explore the usefulness of a head-space gas chromatography in the determination of residual solvents including methanol,ethanol,ethyl ether,and petroleum ether in muscone in artificial musk.
METHODSThe head-space gas chromatography was performed on HP-5(30 m×0.53 mm,5 Μm)capillary column with a hydrogen flame ionization detector. The carrier gas was nitrogen and the solvent was dimethyl sulfoxide. The injector temperature and the detector temperature were controlled at 180 ℃ and 250 ℃,respectively. The containers of head-space injector were preheated at 80 ℃ for 15 minutes. The column temperature was programmed raised,which achieved baseline separation of the components.
RESULTSThe results showed a good linear relationship for methanol,ethanol,ethyl ether,and petroleum ether(60-90 ℃)in the range of each consistency; and the limit of detection was 0.8,1.0,0.1,and 0.3 Μg/ml,respectively. The precision and average recoveries were satisfactory.
CONCLUSIONThe head-space gas chromatography is simple,rapid,and precise technique for measuring residual solvents in muscone.
