Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol.
10.1016/j.apsb.2013.12.008
- Author:
Ryuji UCHIDA
1
,
2
;
Seiko ISHIKAWA
3
;
Hiroshi TOMODA
4
;
Author Information
1. Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan
2. School of Pharmacy, Kitasato University, Tokyo 108-8641, Japan.
3. Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan.
4. Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo 108-8641, Japan
- Publication Type:Journal Article
- Keywords:
2-Hydroxytyrosol;
B16 melanoma cells;
Melanine formation;
Metarhizium sp.;
Tyrosinase inhibitor
- From:
Acta Pharmaceutica Sinica B
2014;4(2):141-145
- CountryChina
- Language:English
-
Abstract:
2-Hydroxytyrosol (2-HT), originally reported as a synthetic compound, was isolated for the first time as a fungal metabolite. 2-HT was found to inhibit mushroom tyrosinase with an IC50 value of 13.0 µmol/L. Furthermore, 2-HT dose-dependently inhibited tyrosinase activity (IC50, 32.5 µmol/L) in the cell-free extract of B16 melanoma cells and α-melanocyte stimulating hormone (α-MSH)-stimulated melanin formation in intact B16 melanoma cells.
