Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer׳s disease.
10.1016/j.apsb.2014.12.006
- Author:
Hongjuan TONG
1
;
Kaiyan LOU
1
;
Wei WANG
2
;
Author Information
1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, Shanghai 200237, China.
2. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, State Key Laboratory of Bioengineering Reactor, East China University of Science and Technology, Shanghai 200237, China
- Publication Type:Journal Article
- Keywords:
AD, Alzheimer’s disease;
APP, amyloid peptide precursor;
Ach, acetylcholine;
Alzheimer׳s disease;
Amyloid-β plagues;
Aβ, amyloid-β;
BAP, BODIPY-based Ab imaging probe;
BBB, blood-brain barrier;
Blood-brain barrier;
Cy, cyanine dyes;
Fluorescence probe;
ICG, indocyanine green dyes;
MRI, magnetic resonance imaging;
NIR, near-infrared;
NIRF, near-infrared fluorescence;
Near-infrared fluorescence;
Optical imaging;
PET, positron emission tomography;
ROS, reactive oxygen species;
SPECT, single photon emission computed tomography
- From:
Acta Pharmaceutica Sinica B
2015;5(1):25-33
- CountryChina
- Language:English
-
Abstract:
One of the early pathological hallmarks of Alzheimer׳s disease (AD) is the deposition of amyloid-β (Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for early diagnosis of AD in the past decades. Optical imaging, particularly near-infrared fluorescence (NIRF) imaging, has emerged as a safe, low cost, real-time, and widely available technique, providing an attractive approach for in vivo detection of Aβ plaques among many different imaging techniques. In this review, we provide a brief overview of the state-of-the-art development of NIRF Aβ probes and their in vitro and in vivo applications with special focus on design strategies and optical, binding, and brain-kinetic properties.
