Interaction and relationship between angiotensin converting enzyme gene and environmental factors predisposing to essential hypertension in Mongolian population of China.
- Author:
Qun XU
1
;
Yan-Hua WANG
;
Wei-Jun TONG
;
Ming-Liang GU
;
Gang WU
;
Batu BUREN
;
Yong-Yue LIU
;
Jian WANG
;
Yong-Shan LI
;
Hua FENG
;
Shuang-Lian BAI
;
Hai-Hua PANG
;
Gui-Rong HUANG
;
Ming-Wu FANG
;
Yong-Hong ZHANG
;
Zheng-Lai WU
;
Chang-Chun QIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Age Factors; Alcohol Drinking; Anthropometry; Blood Glucose; China; Cholesterol; blood; Cross-Sectional Studies; Environmental Exposure; Female; Genetic Predisposition to Disease; Humans; Hypertension; enzymology; etiology; genetics; Male; Middle Aged; Mongolia; ethnology; Peptidyl-Dipeptidase A; genetics; Polymorphism, Genetic; Renin-Angiotensin System; genetics; Risk Factors; Rural Population; Sex Factors; Smoking; Triglycerides; blood
- From: Biomedical and Environmental Sciences 2004;17(2):177-186
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the association of specific functional gene ACE (I/D) variants of the renin-angiotensin system with essential hypertension (EH) and interaction between ACE (I/D) gene and risk factors for EH in a genetically homogenous Mongolia rural population of China.
METHODSIndividuals (n=1099) were recruited from general population of Kezuohouqi Banner in Inner Mongolian Autonomous Region.
RESULTSThe association was found between ACE genotype DD plus ID and EH, with an interaction between ACE genotype DD plus ID and cigarette smoking in an additive model. Cigarette smoking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 7.10 to 1.16. Interaction between ACE genotype DD plus ID and alcohol drinking on EH appeared an additive model. Alcohol drinking index and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 1.66 to 1.09. BMI and ACE gene showed a low exposure-gene (LEG) effect on EH, with interaction indices from 6.15 to 2.49. Interactions between ACE genotype and WHR on EH showed a multiplicative model. In a short,there was an interaction between ACE gene and cigarette smoking, alcohol drinking and BMI on EH, especially in a low dose-exposure effect
CONCLUSIONIt is important for individuals who carry ACE D allele gene to prevent EH, and furthermore, to prevent and control coronary heart disease, in a view of population-based prevention.
