Association of HLA-B alleles with human immunodeficiency virus type 1 infection in the Yi ethnic group in Sichuan province.
- Author:
Ming-Yan XU
1
;
Kun-Xue HONG
;
Xiao-Ling DENG
;
Jun LI
;
Hong PENG
;
Yu-Hua RUAN
;
Guan-Ming QIN
;
Hui XING
;
Xiao-Hu XU
;
Yi-Ming SHAO
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; China; ethnology; DNA; analysis; Ethnic Groups; Gene Frequency; Genetic Predisposition to Disease; Genotype; HIV Infections; blood; genetics; HIV Seropositivity; blood; HIV-1; pathogenicity; HLA-B Antigens; genetics; Humans; Polymerase Chain Reaction; methods; Surveys and Questionnaires
- From: Biomedical and Environmental Sciences 2004;17(2):203-208
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo determine the distribution of HLA-B alleles in the Chinese Yi ethnic group and its association with HIV infection.
METHODSOne hundred and six unrelated healthy HIV negative and 73 HIV positive Chinese Yi ethnic individuals were typed by PCR-SSP.
RESULTSThe frequency of alleles B*07, Bx 35, and B*46 were increased in HIV-1-positive subjects, whereas the alleles B*55, B*44 and B*78 were absent in the HIV-infected persons studied. The B*46 allele was present in a significantly higher gene frequency among HIV-1-positive individuals (P=0.02, OR=3.32, 95% CI=1.13-9.78) compared with control subjects.
CONCLUSIONHLA-B*46 may be associated with its susceptibility to HIV-1 infections.
