Evaluation on HBeAg conversion time when treating chronic hepatitis B patients with combination of lamivudine and traditional Chinese medicine

VernacularTitle:拉米夫定联合中药干预慢性乙型肝炎发生HBeAg血清学转换时间的系统评价
Author: Song-Lin BAI ¹ ; Xiao-Yu HU ; Sen ZHONG
Author Information

1. 成都中医药大学附属医院
Keywords: Chronic hepatitis B; Lamivudine; Traditional Chinese medicine; Systematic review
From: Chinese Journal of Epidemiology 2008;29(12):1243-1247
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of the combined use of traditional Chinese medicine and lamivudine(LMD) in treating chronic hepatitis B patients, and to follow the serological response for six months or longer. Methods CNKI, Wanfang data, VIP data, CBMdisk, MEDLINE,EMBASE,BIOSIS and Cochrane Central Register of Controlled Trials database and literature were searched, to include randomized controlled trails (RCT) that used LMD alone or combined with traditional Chinese medicine. RevMan 4.2 was used for data analysis. Results The Meta analysis of 7 trails demonstrated that the HBeAg conversion rate in treatment group was higher than those from the control group, and the differences were statistically significant at 6, 9, 12 months. Conclusion Data demonstrated that early intervention of traditional Chinese medicine might increase the HBeAg conversion rate but conclusion needs to be more specific to the types of trials.