Meta-analysis on the relationship between colorectal cancer and Helicobacter pylori infection
10.3760/cma.j.issn.0254-6450.2009.01.020
- VernacularTitle:幽门螺杆菌感染与大肠癌关系的Meta分析
- Author:
Yan ZHANG
1
;
Chang GAO
;
Jing-Hua ZHAI
Author Information
1. 济宁医学院
- Keywords:
Helicobacter priori;
Colorectal cancer;
Meta-analysis
- From:
Chinese Journal of Epidemiology
2009;30(1):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective Analyzing all the related studies that have been published in the world to evaluate the relationship between colorectal cancer (including colorectal adenomas) and Helicobacter priori ififection by means of Meta-analysis.Methods To analyze the 14 references consistent with inclusion criteria by reviewing manager 4.2,calculating the odds ratio and 95% confidence interval,then drawing funnel plot.Results The total sample size is 3165,cases and controls are 1330 and 1835,respectively.The pooled OR is 1.36,and 95% confidence interval 1.01,1.82.The graphical funnel plot appearing asymmetrical,but analyzing by sensitivity analysis and fail-safe number calculation.The results are affected by publication bias.Conclusion The results of our Meta-analysis show that Helicobacter priori infection is a possible risk of colorectal cancer.
