Studies on the relationship between D6S1581, a high frequency allele imbalance locus, and genetic susceptibility to nasopharyngeal carcinoma.
- Author:
Wei XIONG
1
;
Zhao-yang ZENG
;
Shou-rong SHEN
;
Xiao-ling LI
;
Wei-fang LI
;
Rong WANG
;
Fang XIONG
;
Cong PENG
;
Qiu-hong ZHANG
;
Ming ZHOU
;
Yi-xin YANG
;
Hou-de ZHOU
;
He HUANG
;
Gui-yuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alleles; China; F-Box Proteins; genetics; Female; Gene Frequency; Genetic Linkage; Genetic Predisposition to Disease; genetics; Humans; Male; Microsatellite Repeats; genetics; Middle Aged; Nasopharyngeal Neoplasms; genetics; Pedigree
- From: Chinese Journal of Medical Genetics 2003;20(4):311-314
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of nasopharyngeal carcinoma (NPC) with the high frequency allele imbalance locus D6S1581, and the NPC associated gene FBXO30 which is located near D6S1581.
METHODSGenescan was used to genotype D6S1581 of 12 NPC pedigrees, 85 sporadic NPC patients and 181 normal volunteers. Then parametric/nonparametric linkage analysis and association analysis were performed.
RESULTSD6S1581 was linked with NPC, a Lod score of 2.611436 (P=0.00245) was obtained, and a significant difference in allele frequency was observed between familial NPC and control (P<0.005).
CONCLUSIONThese results suggest that D6S1581 is highly associated with NPC, and there may be one or more NPC associated genes near D6S1581, including FBXO30.
