Study on the distribution of vitamin D receptor gene start codon polymorphism in the Achangs and Hans.
- Author:
Ji-mei LI
1
;
Hua-jun LU
;
Hai-lin LI
;
Rui-zhu TANG
;
Xiao-xian WANG
;
Ping HAO
Author Information
- Publication Type:Journal Article
- MeSH: China; Codon, Initiator; genetics; Humans; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Receptors, Calcitriol; genetics
- From: Chinese Journal of Medical Genetics 2003;20(4):315-317
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the difference between the Chinese Achang and Han ethnic groups in Yunnan province in the distribution of vitamin D receptor (VDR) gene start codon polymorphism.
METHODSPolymerase chain reaction-restriction fragment length polymorphism, gene sequencing and genetic analysis methods were used. A restriction fragment length polymorphism in the start codon of VDR (Fok I) gene was tested in the Achangs (n=68) and the Hans (n=92).
RESULTSThe frequencies of FF, Ff and ff genotypes were found to be 18%, 35% and 47% in the Achangs, and 22%, 52% and 26% in the Hans, respectively. A significant difference was seen in the frequency distribution of VDR genotype between the Achangs and the Hans(Chi2=7.716, P=0.021).
CONCLUSIONThe Achang and Han ethnic groups differ in the frequency distribution of VDR gene start codon polymorphism.