The frequency distribution of flavin-containing monooxygenase 3 mutant alleles in 28 populations from Yunnan.
- Author:
Wei-min ZENG
1
;
Jie YANG
;
Yong-li DONG
;
Hong SHI
;
Lu GAO
;
Zhi-li YANG
;
Jin LU
;
Zhao-jing HAO
;
Chun-jie XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; China; Gene Frequency; Genotype; Humans; Mutation; Oxygenases; genetics
- From: Chinese Journal of Medical Genetics 2003;20(4):318-321
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the frequency distribution of flavin-containing monooxygenase 3 (FMO3) mutant alleles in 28 populations originating from 24 ethnic minorities in Yunnan of China.
METHODSFMO3 genotypes were analyzed by polymerase chain reaction-restriction fragment length polymorphism.
RESULTSThe average frequencies of FMO3/Stop(148), FMO3/Lys(158) and FMO3/Gly(308) were 0.395(0.174-0.803), 0.208 (0.056-0.414), 0.046(0-0.217), respectively. The frequencies of FMO3/Gly(308) in Blang, Huayaodai, Shuidai, Zhuang, De'ang, Jingpo, Nu and Hui populations were null.
CONCLUSIONIt was found that the frequencies of FMO3 mutant alleles varied not only in different ethnic groups, but also in different populations that stemmed from the same ethnic group.
