Association analysis between attention-deficit hyperactivity disorder and Val158Met polymorphism of catechol-O-methyltransferase gene.
- Author:
Xian-ning ZHANG
1
;
Lie-min RUAN
;
Yan-ping LE
;
Ye ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Attention Deficit Disorder with Hyperactivity; enzymology; genetics; Catechol O-Methyltransferase; genetics; Child; Exons; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Humans; Male; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2003;20(4):322-324
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between attention-deficit hyperactivity disorder (ADHD) in Han Chinese children and Val158Met polymorphism of catechol-O-methyltransferase (COMT) gene caused by the missense mutation of G158A in exon 4.
METHODSBy using polymerase chain reaction-restriction fragment length polymorphisms the Val158Met polymorphism of COMT gene was tested in 117 children with the diagnosis of ADHD as defined by DSM-IV and in 105 healthy controls living in Shanghai.
RESULTSThe frequencies of A allele were 25.21% and 23.81% in the ADHD group and the health controls respectively, which showed no significant difference between the two groups (Chi2=0.5197, P>0.05). There was also no significant difference in the distribution of all genotypes of COMT gene between the ADHD patients and the controls (P>0.05).
CONCLUSIONIt was suggested that for the Han Chinese children with ADHD in this study, there was no association between ADHD and Val158Met polymorphism of COMT gene.
