Study on the genic polymorphism of HLA-DRB1 in a population in the north of China.
- Author:
Dan LI
1
;
Hai-yan LIU
;
Bin XI
;
Yan YU
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; China; Female; Gene Frequency; Genetics, Population; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Humans; Infant, Newborn; Male; Polymerase Chain Reaction; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2003;20(4):325-327
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate at the DNA level the polymorphism of HLA-DRB1 gene in Han population in Beijing of China.
METHODSThis study was conducted in the Hans in Beijing. A total of 2810 normal and unrelated neonates were analyzed and subjected to HLA-DRB1 low resolution typing, and from among them 217 neonates were randomly selected for DRB1 high resolution typing by polymerase chain reaction-sequence specific primers technique.
RESULTSFourteen HLA-DRB1 specificity and 39 alleles were found with HLA-DRB1 *09012, *1501, *07011, *08032 as the most common genes. Their gene frequencies and allelic distributions were compared to those observed in other ethnic populations.
CONCLUSIONThe results showed the characteristic of HLA-DRB1 distribution, and provided more comprehensive and accurate gene data that may serve as normal reference values for the population in Beijing, China.
