Transmission disequilibrium test of polymorphisms of serotonin transporter gene and schizophrenia based on family trios.
- Author:
Wei-wei SUN
1
;
Jin-bo FAN
;
Xue-qing QIAN
;
Jun-xia TANG
;
Yang-lin XING
;
Jian-guo SHI
;
Shao-min ZHU
;
Hui-jun LIU
;
Niu-fan GU
;
Guo-yin FENG
;
Lin HE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Genetic Predisposition to Disease; genetics; Humans; Male; Minisatellite Repeats; genetics; Nuclear Family; Polymerase Chain Reaction; Polymorphism, Genetic; Schizophrenia; genetics; Serotonin Plasma Membrane Transport Proteins; genetics
- From: Chinese Journal of Medical Genetics 2003;20(4):342-344
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between two polymorphisms (Intronic VNTR and 5-HTTLPR) of the serotonin transporter gene and schizophrenia.
METHODSA set of 314 schizophrenic trio samples collected from Shanghai, Xi'an and Jilin regions of China independently was subjected to analysis of the polymorphisms by transmission/disequilibrium test(TDT).
RESULTSNo significantly preferential transmission of any allele was detected from both polymorphisms investigated.
CONCLUSIONThe results suggest that the serotonin transporter gene is unlikely to have a major contribution to susceptibility to schizophrenia in Han Chinese population.
