The association between glucocorticoid receptor gene G1666T polymorphism and cerebral infarction in Chinese.
- Author:
Lan-qin CHI
1
;
Chen ZHANG
;
Bing LUO
;
Hao-yun SUN
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; Cerebral Infarction; ethnology; genetics; China; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Humans; Male; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptors, Glucocorticoid; genetics
- From: Chinese Journal of Medical Genetics 2003;20(4):353-356
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo ascertain whether the human glucocorticoid receptor (GR) gene polymorphism is associated with cerebral infarction (CI) and essential hypertension (EH) in Chinese.
METHODSThis is a case-control study of Chinese DNA samples abstracted from 163 subjects. The samples were analysed by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to determine the intron 4 variant of human GR gene.
RESULTSBy analysis of the samples from both sexes as a whole, no association was observed between the EH+CI group and control group, and between the CI group and control group. However, by analysis of the samples from the females, weak association was observed between the EH+CI group and control group, and between the CI group and control group; the frequency of allele G was 0.64 for the EH+CI group, 0.69 for CI group and 0.46 for control group.
CONCLUSIONThe G allele may be a predisposing gene marker, GR gene intron 4 polymorphism contributes to the development of CI in females.
