Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease.
- Author:
Jing-jing SU
1
;
Hui-jun XIE
;
Wu-wei ZHAO
;
Hai-xiong HAN
;
Tong GAO
;
Ling XU
;
Guo-mei TANG
;
Da-ming REN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alleles; Gene Frequency; Genotype; Humans; Middle Aged; Nerve Tissue Proteins; genetics; Parkinson Disease; genetics; Polymorphism, Single Nucleotide; Synucleins; gamma-Synuclein
- From: Chinese Journal of Medical Genetics 2003;20(5):444-446
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area.
METHODSPolymorphic genotyping was performed with PCR-RPLP technique. Association analysis was carried out in 145 unrelated idiopathic PD patients and 184 age-matched healthy controls.
RESULTSThe authors failed to detect any distributional difference of the C243G and A377T polymorphisms of the gamma-synuclein gene between PD cases and control subjects, nor did they find any association.
CONCLUSIONThese data do not support that gamma-synuclein gene C243G and A377T polymorphisms are involved in idiopathic PD onset in the Han population of Shanghai area.
