Polymorphism of c-Ha-ras 3'VNTR in hydatidiform mole and its relationship with the development of postmolar tumor.
- Author:
Fang WANG
1
;
Xu KANG
;
Bi CHEN
;
Jiang-ling PANG
;
Ying-yong LI
Author Information
- Publication Type:Journal Article
- MeSH: 3' Flanking Region; genetics; DNA Mutational Analysis; methods; DNA, Neoplasm; genetics; Electrophoresis, Polyacrylamide Gel; Female; Genes, ras; genetics; Humans; Hydatidiform Mole; genetics; Male; Minisatellite Repeats; genetics; Nucleic Acid Amplification Techniques; Polymorphism, Genetic; Pregnancy; Retrospective Studies; Uterine Neoplasms; genetics
- From: Chinese Journal of Medical Genetics 2003;20(5):452-453
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the polymorphism of c-Ha-ras 3' variable number of tandem repeat (VNTR) and its relationship with development of postmolar tumor.
METHODSThe cases of hydatidiform mole (HM) were retrospectively analyzed by amplified fragment length polymorphism-polyacrylamide gel electrophoresis. The DNA origin of HM was determined by comparison with the parents' DNA amplified results.
RESULTSAmong the samples from 15 cases, DNA from only paternal origin was found in 2 cases. DNA from both parents was in 13 cases, and of these 13 cases, 2 were found to be had balanced DNA origin, 11 had more DNA form paternal origin than DNA from maternal origin.
CONCLUSIONThe HM which has DNA from both parents origin and predominantly from paternal origin developed to postmolar tumor more frequently.
