Study on association between CC16 gene G38A mutation and asthma in the patients of Han population in Chongqing, China.
- Author:
Qing GUI
1
;
Gui-sheng QIAN
;
Gui-jun HUANG
;
Shu-ping LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alleles; Asthma; genetics; China; ethnology; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Mutation; Proteins; genetics; Uteroglobin
- From: Chinese Journal of Medical Genetics 2003;20(6):542-543
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the possible association between polymorphism of CC16 gene exon 1 and asthma, the genotype and allele frequencies of CC16 gene exon 1 in the asthmatic patients of Han population in southwest China were analyzed.
METHODSThe authors determined the genotypes of CC16 gene exon 1 with polymerase chain reaction technique and restricted enzyme analysis, and then compared the genotype and allele frequencies of the gene of the asthmatic group with those of the healthy control group.
RESULTSThere was no significant difference in genotype and allele frequencies of CC16 gene between the asthmatic group and control group. There was no association between the genotype and allele frequencies of gene and the severity of asthma.
CONCLUSIONCC16 gene may be not a susceptibility gene of asthmatic patients of Han population in southwest China.
