Relationship between six single nucleotide polymorphisms of angiotensinogen gene and essential hypertension.
- Author:
Yan LIU
1
;
Wei JIN
;
Zheng-wen JIANG
;
Kui-xing ZHANG
;
Hai-hui SHENG
;
Lin JIN
;
Ya-yun SHENG
;
Wei HUANG
;
Jin-de YU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Angiotensinogen; blood; genetics; Female; Haplotypes; Humans; Hypertension; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2004;21(2):116-119
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the relationship of six single nucleotide polymorphisms(SNPs) and their haplotypes of angiotensinogen(AGT) gene to essential hypertension(EH) in Chinese Han population.
METHODSThe genotypes in 185 patients with EH and 185 healthy controls were determined by the method of ABI PRISM SNaPshot Multiplex Kit using six AGT gene polymorphisms at position -217(G/A), -152(G/A), -20(A/C) and -6(G/A) in the promoter region and T174M, M235T in exon 2.
RESULTSThe distribution of AGT genotypes and alleles frequencies showed no significant difference between the group of EH and group of controls (P>0.05). However, haplotype analysis revealed that H4 haplotype frequency, which included -152A, -20C, -6A and 235T alleles, was significantly increased in the group of EH (P<0.05).
CONCLUSIONG-152A, A-20C, G-6A and M235T polymorphisms of AGT gene might play an important role in the occurrence of EH in Chinese Han population.
