Survey of coronary stents development for restenosis prevention.
- Author:
Jie CHEN
1
;
Zhonghua NI
;
Xingzhong GU
Author Information
1. Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing. cjgrace@sina.com
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
Blood Vessel Prosthesis;
Coronary Restenosis;
prevention & control;
Equipment Design;
Hemodynamics;
Models, Cardiovascular;
Shear Strength;
Stents
- From:
Chinese Journal of Medical Instrumentation
2009;33(6):429-434
- CountryChina
- Language:Chinese
-
Abstract:
Coronary stents are playing an effective way of curing cardiovascular diseases while a major drawback of restenosis is in general still present. Restenosis is resulting from neointimal hyperplasia and thrombosis which induced by the vascular lesion, hemodynamic modification and the reduction or oscillation of wall shear stress (WSS). The crucial factors that would determine the restenosis were reviewed in this paper, including the material bio-compatibilities, surface treatments, stent configuration designs and hemodynamics analyses. In particular, the hemodynamics after stents implantation based on in vivo, in vitro or Computational Fluid Dynamics (CFD) methods was discussed. A novel CFD and experimental approach of dynamics in the stent-vascular coupling system was proposed.
