Identification of hepatitis B virus intergenotype recombination in Chinese patients.
- Author:
Deng PAN
1
;
Bin ZHOU
;
Jie YANG
;
Jinlin HOU
Author Information
- Publication Type:Journal Article
- MeSH: Genome, Viral; Genotype; Hepatitis B virus; genetics; isolation & purification; Humans; Phylogeny; Recombination, Genetic
- From: Journal of Southern Medical University 2014;34(10):1436-1442
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the intergenotype recombination of hepatitis B virus (HBV) in Chinese patients and explore new recombination types of HBV.
METHODSComplete genome sequences of HBV from Chinese patients were downloaded from GenBank and analyzed by Fragment-typing method to screen the potential recombinants, and the breakpoints of recombination were identified by using Simplot program.
RESULTSThirty-one recombination types including 755 recombinants were identified from 1642 complete HBV genome sequences, including 22 B/C recombination types with 676 recombinants, 5 C/D recombination types with 75 recombinants, 3 A/C recombination types with 3 recombinants, and 1 C/I recombination type with 1 recombinant.
CONCLUSIONOf the 31 recombination types comprising 755 recombinants, 4 are novel recombination types found for the first time. All these recombination types identified in this study involve genotype C.
