Expression of miR-126/miR-126* in hepatocelluar carcinoma and its correlation with clinical outcomes.
- Author:
Hua HE
1
;
Yu HUANG
;
Dinghua YANG
;
Bo LIANG
;
Liang LIN
;
Jia-Lu LI
;
Hui LIAO
;
Botang GUO
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Hepatocellular; genetics; metabolism; Down-Regulation; Humans; Liver Neoplasms; genetics; metabolism; MicroRNAs; genetics; metabolism; Neoplasm Recurrence, Local; Real-Time Polymerase Chain Reaction
- From: Journal of Southern Medical University 2014;34(10):1493-1497
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of miR-126/miR-126* in hepatocellular carcinoma (HCC) tissues and its clinical significance.
METHODSThe expressions of miR-126/miR-126* in the tumor tissues and non-cancer tissues from 74 HCC cases were detected using real-time quantitative PCR. The correlation between miR-126/miR-126* expression and the clinicopathological features of the patients was analyzed.
RESULTSCompared with the non-cancer tissues, HCC tissues showed significantly lowered expression levels of miR-126/miR-126*. A positive correlation was found between the expressions of miR-126 and miR-126* in the tumor tissues. Lower expressions of miR-126/miR-126* were significantly correlated with tumor recurrence and poor survival of the HCC patients.
CONCLUSIONThe down-regulation of miR-126/miR-126* may play an important role in HCC metastasis and contributes to poor survival of HCC patients.
