Establishment of blood β-hydroxybutyrate threshold for diagnosis of type 2 diabetes ketoacidosis.
- Author:
Peifeng KE
1
;
Haitao ZHOU
;
Zemin WANG
;
Xiaobin WU
;
Haibiao LIN
;
Xianzhang HUANG
Author Information
- Publication Type:Journal Article
- MeSH: 3-Hydroxybutyric Acid; blood; Diabetes Mellitus, Type 2; blood; Diabetic Ketoacidosis; blood; diagnosis; Humans; Sensitivity and Specificity; Severity of Illness Index
- From: Journal of Southern Medical University 2014;34(10):1507-1510
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish of blood beta hydroxybutyrate (βOHB) threshold for diagnosing type 2 diabetes ketoacidosis (DKA) and explore the relationship between βOHB levels and the severity of DKA.
METHODSCorrelation analysis was performed between serum βOHB and [HCO(3)] in type 2 diabetic patients admitted in the emergency department in the past year. Regression equation was used to calculate the concentration of βOHB corresponding to a [HCO(3)] level of 18.0, 15, and 10.0 mmol/L, and βOHB concentration corresponding to a [HCO(3)] level of 18.0 mmol/l was used as the DKA diagnostic threshold.
RESULTSThe serum βOHB level and [HCO3] concentration showed a good correlation (R²=0.7023, P<0.001). βOHB concentrations that corresponded to a [HCO(3)] level of 18.0, 15, and 10.0 mmol/L were 3.0, 4.70, and 7.5 mmol/L, respectively, in accordance with the severity of DKA. Combined with the blood glucose concentration ≥ 13.9 mmol/L, a blood βOHB≥3.0 mmol/L showed a sensitivity of 99%, specificity of 86%, and total effectiveness of 92.81% for diagnosing DKA.
CONCLUSIONA serum βOHB level above 3.0 mmol/L can be used as the diagnostic threshold of DKA. βOHB can serve as an index for assessing the severity of DKA.