Low and maternal-specific expression of p57KIP2 in hydatidiform mole and its clinical implication.
- Author:
Yali XIONG
1
;
Yang CAO
;
Hongfa LI
Author Information
1. Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
- Publication Type:Journal Article
- MeSH:
Cyclin-Dependent Kinase Inhibitor p57;
Cyclin-Dependent Kinases;
antagonists & inhibitors;
Enzyme Inhibitors;
metabolism;
Female;
Genomic Imprinting;
genetics;
Humans;
Hydatidiform Mole;
genetics;
metabolism;
Nuclear Proteins;
biosynthesis;
genetics;
Placenta;
metabolism;
Pregnancy;
RNA, Messenger;
biosynthesis;
genetics;
Uterine Neoplasms;
genetics;
metabolism
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2002;22(2):121-157
- CountryChina
- Language:English
-
Abstract:
In situ hybridization was applied to locate and detect the expression of p57KIP2 in hydatidiform mole (5 cases of partial hydatidiform mole and 18 cases of complete hydatidiform mole) and normal villi (23 cases). The positive signals of p57KIP2 expression were analyzed by HPIAS-1000 Image-Analysis System. p57KIP2 was highly expressed in normal villi but showed distinct low expression in hydatidiform mole (P < 0.01). Furthermore, the locus of low expression of p57KIP2 accorded with the place where lesion of trophoblast occurred. Detection of p57KIP2 made it possible to study the genetics of hydatidiform mole at the transcriptional level. Low expression of p57KIP2 could be a molecular marker in hydatidiform mole and a target for therapy.
