Study on the effects of FCu-IUD and FICu-IUD on matrix metalloproteinases in human uterine flushing and endometrium.
- Author:
Wei LI
1
;
Lumin CAO
;
Zaojao CHEN
;
Wan LI
;
Qingling DU
;
Guiping CHEN
Author Information
1. Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
- Publication Type:Journal Article
- MeSH:
Adult;
Endometrium;
enzymology;
Female;
Humans;
Indomethacin;
Intrauterine Devices, Copper;
adverse effects;
Intrauterine Devices, Medicated;
adverse effects;
Matrix Metalloproteinases;
metabolism;
Middle Aged;
Uterine Hemorrhage;
etiology;
prevention & control
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2002;22(1):9-16
- CountryChina
- Language:English
-
Abstract:
The activity of matrix metalloproteinases (MMPs) in the uterine flushing and endometrial tissue of normal adult women wearing FCu-IUD (fixed Cu-IUD) or FICu-IUD (indomethacin-releasing FCu-IUD) was observed by using zymography on SDS-PAGE containing gelatin. The results showed that the activity and kinds of MMPs in FCu-IUD group were increased significantly as compared with themselves before being inserted FCu-IUD. However, compared with the FCu-IUD group, the activity of some kinds of MMPs in the FICu-IUD group was decreased significantly. These data suggest that IUD can enhance the activity of MMPs in human endometrium, intermediated by prostaglandins, and MMPs may have relation to IUD-induced menorrhagia and indomethacin reduces IUD-induced menorrhagia by partly inhibiting MMPs synthesis.
