OBJECTIVETo discuss the impacts of abdominal acupuncture on serum leptin, adiponectin, total cholesterol and triglyceride in the patients of obesity induced by olanzapine.

METHODSEighty-six obesity patients induced by olanzapine were randomized into an observation group (47 cases) and a control group (39 cases). The healthcare guide and the adjustment on diet and physical exercise were given in the two groups. Additionally, in the observation group, the abdominal acupuncture therapy was applied to Zhongwan (CV 12), Xiawan (CV 10), Qihai (CV 6), Guanyuan (CV 4), Tianshu (ST 25) and Shuidao (ST 28), once a day, 5 times a week. The treatment lasted for 3 months in the two groups. The body mass index (BMI), serum leptin, adiponectin, total cholesterol and triglyceride were compared before and after treatment in the patients of the two groups.

RESULTSAfter treatment, BMI, serum leptin, total cholesterol and triglyceride were all lower than those before treatment in the patients of the two groups (all<0.05). Adiponectin was higher than that in the two groups before treatment (both<0.05). After treatment, BMI, serum leptin, total cholesterol and triglyceride in the observation group were apparently lower than those in the control group (all<0.05) and adiponectin was higher than that in the control group (<0.05).

CONCLUSIONSAbdominal acupuncture regulates the transfer capacity of leptin signal and the secretion of adiponectin, promotes lipid metabolism and reduces the body mass in obesity patients induced by olanzapine.