Analysis of predictive factors affecting sentinel lymph node status in early breast cancer patients.

Dechuang Jiao; Jianghua Qiao; Zhenduo LU; Lianfang LI; Hengwei Zhang; Hui Liu; Shude Cui; Zhenzhen Liu

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Analysis of predictive factors affecting sentinel lymph node status in early breast cancer patients.

Author: Dechuang JIAO ^{1
,

2} ; Jianghua QIAO ¹ ; Zhenduo LU ¹ ; Lianfang LI ¹ ; Hengwei ZHANG ¹ ; Hui LIU ¹ ; Shude CUI ¹ ; Zhenzhen LIU ¹ ;
Author Information

1. Department of Breast Surgery, Affiliated Cancer Hospital of Zhengzhou University
2. Henan Cancer Hospital, Zhengzhou 450008, China.
Publication Type:Journal Article
MeSH: Adult; Aged; Aged, 80 and over; Breast Neoplasms; metabolism; pathology; surgery; Carcinoma, Ductal, Breast; metabolism; pathology; surgery; Female; Humans; Ki-67 Antigen; metabolism; Lymph Node Excision; Lymph Nodes; pathology; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Receptors, Estrogen; metabolism; Receptors, Progesterone; metabolism; Retrospective Studies; Sentinel Lymph Node Biopsy; Tumor Burden; Young Adult
From: Chinese Journal of Oncology 2014;36(3):198-201
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the predictive factors affecting sentinel lymph node status in early breast cancer patients.
METHODSClinicopathological data of 1 038 patients with early breast cancer, who underwent sentinel lymph node biopsy in Henan Tumor Hospital between July 2010 and August 2013, were reviewed. Logistic regression analysis was performed to identify the relevance of clinicopathological features with sentinel lymph node metastases.
RESULTSThis group was consisted of 1 038 female patients with an average of 48.6 years. Positive sentinel lymph nodes were found in 22.9% (238/1 038) of the patients. The average number of sentinel lymph nodes removed by surgery was 3.8. Tumor size, tumor location, histopathology, ER/PR status and Ki-67 level were significantly correlated with SLN metastasis(P < 0.05 for all). All the above factors but Ki-67 level were significant independent predictors for SLN metastasis(P < 0.01 for all).
CONCLUSIONNegative hormone receptor status, invasive cancer of non-specific histopathological type, tumor size >2 cm, and tumor location in the outer upper quadrat are independent predictive factors of sentinel lymph node metastasis in patients with early breast cancer.