Relationship between heat shock protein 70-hom gene polymorphism and ankylosing spondylitis.
- Author:
Jing-an LIN
1
;
De-fu YE
;
Yue-yong ZHU
;
Jun-min CHEN
;
Wei-qing ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Child; Female; HSP70 Heat-Shock Proteins; genetics; Humans; Male; Middle Aged; Polymorphism, Genetic; Spondylitis, Ankylosing; genetics
- From: Chinese Journal of Medical Genetics 2004;21(2):182-183
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between heat shock protein 70-hom (HSP70-hom) gene polymorphism and ankylosing spondylitis(AS) in Chinese Han patients.
METHODSGenomic DNA from 98 Chinese AS patients and 70 ethnically matched controls were typed for HSP70-hom polymorphism by polymerase chain reaction-restriction fragment length polymorphism.
RESULTSThe HSP70-hom genotypes in the AS patients consisted of homozygote AA (60.2%) and BB(4.1%), and heterozygote(35.7%), while the HSP70-hom genotypes in the controls were composed of AA(58.6%), BB(2.9%) and heterozygote(38.6%). No significant difference was found in the distribution of HSP70-hom genotype between these two groups(chi(2) test=0.280, P>0.05). The frequencies of HSP70-hom alleles in AS patients were 77.9%(AA) and 22.1%(BB), while they were 78.1% and 21.9% in the controls. The frequency of HSP70-hom allele in AS patients was not significantly increased, compared with that in controls (chi(2) test=0.002, P>0.05).
CONCLUSIONThere may be no association between the HSP70-hom gene polymorphism and ankylosing spondylitis in Chinese Han population.
