The relationship of angiotensin I-converting enzyme gene polymorphism with diabetic retinopathy and diabetes myocardial infarction.
- Author:
Shou-shan WU
1
;
Qing-mei GUO
;
Ge-ling LIU
;
Juan ZHANG
;
Chen-fu ZHAO
;
Shu-cheng NING
;
Li-na ZHAO
;
Fang YU
;
Hong-li YI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Diabetes Mellitus, Type 2; complications; Diabetic Retinopathy; etiology; genetics; Female; Humans; Male; Middle Aged; Myocardial Infarction; etiology; genetics; Peptidyl-Dipeptidase A; genetics; Polymorphism, Genetic; Risk Factors
- From: Chinese Journal of Medical Genetics 2004;21(3):283-285
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of angiotensin I-converting enzyme (ACE) gene polymorphism to diabetic retinopathy and diabetes myocardial infarction.
METHODSACE insertion/deletion(I/D) polymorphism was determined by PCR.
RESULTSNo evidence showed that ACE gene was associated with diabetic retinopathy. By comparison of the type 2 diabetes patients with myocardial infarction versus those without-myocardial infarction, it was found that the frequencies of homozygote DD (41.2% versus 33.2%) and of allele D (64.7% versus 55.0%) increased remarkably; the difference was statistically significant (P<0.05).
CONCLUSIONAllele D(RR=1.50) and genotype DD(RR=1.33) seemed to be a genetic risk factor for type 2 diabetes myocardial infarction.
