Study on the association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes in Yunnan Han nationality.
- Author:
Hong-ying YANG
1
;
Wen-lin TAI
;
Hui-yun YUAN
;
Mian XU
;
Jiang LI
;
Chun-feng REN
;
Juan DU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alleles; China; ethnology; Diabetes Mellitus, Type 2; genetics; Female; HLA-DQ Antigens; genetics; HLA-DQ alpha-Chains; Humans; Male; Middle Aged; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2004;21(3):291-293
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between the polymorphism of HLA-DQA1 alleles and type 2 diabetes mellitus in Yunnan Hans.
METHODSPolymerase chain reaction-sequence specific primers(PCR-SSP) genotyping method was conducted in 108 Han patients with type 2 diabetes and 56 ethnically matched controls from the same area of Yunnan Province.
RESULTSHLA-DQA1*0301(RR=3.092, P<0.01) and DQA1*0501 (RR=3.257, P<0.05) allelic frequencies in type 2 diabetic patients were significantly higher than those in non-diabetic control subjects respectively. HLA-DQA1*0401 (RR=0.371, P<0.01) allelic frequencies in patients were significantly decreased, compared with controls; HLA-DQA1*0302 (RR=3.356, P<0.01) allelic frequencies in patients with type 2 diabetic nephropathy were significantly increased.
CONCLUSIONHLA-DQA1*0301 and DQA1*0501 are susceptible genes of type 2 diabetes in Yunnan Han nationality; in reverse, HLA-DQA1*0401 is a resistant gene. HLA-DQA1*0302 is a susceptible gene of type 2 diabetic nephropathy.
