The alpha-synuclein gene microsatellite polymorphism and late-onset sporadic Parkinson's disease susceptibility.
- Author:
Xiao-ping ZHAO
1
;
Hui-min ZHENG
;
Hui-jun XIE
;
Su-ju DING
;
Da-ming REN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Age of Onset; Aged; Amplified Fragment Length Polymorphism Analysis; China; epidemiology; Female; Genetic Predisposition to Disease; genetics; Humans; Male; Microsatellite Repeats; genetics; Middle Aged; Odds Ratio; Parkinson Disease; epidemiology; genetics; Polymorphism, Genetic; alpha-Synuclein; genetics
- From: Chinese Journal of Medical Genetics 2004;21(4):339-341
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association of the microsatellite polymorphisms in the promoter region of alpha-synuclein gene with the late-onset sporadic Parkinson's disease (PD) susceptibility.
METHODSThe microsatellite polymorphism of alpha-synuclein gene was analyzed with amplified fragment length polymorphism (Amp-FLP) and semiautomatic fluorescent labeled genotyping technique. Association analysis was performed in 135 unrelated late-onset sporadic PD patients and 170 age-matched healthy controls.
RESULTSThe distribution of the alleles of the dinucleotide repeats variants of alpha-synuclein gene promoter region in PD cases was significantly different from that in the healthy controls. The most frequent allele in PD patients was allele 269 bp, but in controls it was the 271 bp allele. Alleles of
CONCLUSIONalpha-synuclein microsatellite polymorphism might be a genetic susceptibility factor for late-onset sporadic PD.
