Molecular pharmacogenetic studies of drug responses to obsessive-compulsive disorder and six functional genes.
- Author:
Lan ZHANG
1
;
Xiehe LIU
;
Tao LI
;
Yanchun YANG
;
Xun HU
;
David COLLIER
Author Information
- Publication Type:Clinical Trial
- MeSH: Adolescent; Adult; Catechol O-Methyltransferase; genetics; Female; Humans; Male; Monoamine Oxidase; genetics; Obsessive-Compulsive Disorder; drug therapy; genetics; Pharmacogenetics; methods; Receptor, Serotonin, 5-HT2A; genetics; Receptors, Dopamine D2; genetics; Receptors, Dopamine D4; genetics; Serotonin Plasma Membrane Transport Proteins; genetics; Serotonin Uptake Inhibitors; therapeutic use; Treatment Outcome; Young Adult
- From: Chinese Journal of Medical Genetics 2004;21(5):479-481
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the associations between the drug responses to obsessive -pulsive disorder (OCD) and six functional genes related with serotonin and dopamine.
METHODSOne hundred and thirteen OCD nuclear families were collected. The OCD patients were treated with serotonin reuptake inhibitors (SRIs) for 8 weeks and the drug responses were assessed using the Yale-Brown obsessive-compulsive scale (Y-BOCS). The patients were divided into drug responders group and non-responders group according to the reducing rate of Y-BOCS score. The genotypes of six genes were determined with the Amp-FLP and Amp-RFLP techniques and analyzed by transmission disequilibrium test (TDT). The six genes are serotonin 2A receptor (5-HT2A), serotonin transporter (5-HTT), dopamine D2 receptor ( DRD2), dopamine D4 receptor (DRD4), catechol-O- methyltransferase (COMT) and monoamine oxidase A (MAOA).
RESULTSNo association was found between the six genes and different drug responses groups. However, there was significant difference between the drug responders and non-responders in homozygosity at the 5-HT2A -1438G/A locus (chi(2)=4.69, P=0.03).
CONCLUSIONThe results suggested that the 5-HT2A may play some roles in the effects of drug treatment on OCD.
